Article #:
0112-02
Antigen/Product:
NFATc2, NFATp, nuclear factor of activated T-cells
Synonym(s):
NFATc2
Uni-/SwissProt #:
Q60591, A2APK2, Q91Y65
Clone / Name:
IG-209
Host Species:
rabbit
Mono-/polyclonal:
polyclonal (pAB) | anti-(full-length protein)
Purity:
affinity purified on the antigen
Quantity (mass):
20 µg
Quantity (vol.):
100 µl
Price (net):
320.00 €
Cross-reactivity:
human
Applications:
WB - Western blot / immunoblot, IF - immunofluorescence, IHC - immuno-histochemistry, IP - immunoprecipitation, ChIP - chromatin immunoprecipitation
Sugg. dilutions:
WB: (1:500); IF: (1:50); IP: (1:100); ChIP (1:100)
Fixatives tested:
formaldehyde
Form:
sterile filtered liquid, with sodium azide, stabilized with carrier
Immunization:
recombinant protein (full-length)
Storage:
-20°C
Shipping:
cold pack
Availability:
in stock
Data sheet:
Publications referring to this product:
1.
Shaked, I. & Ley, K. Methods of Inhibiting Inflammation and Inflammatory Diseases Using Gal-3bp (btbd17b, Lgals3bp, Galectin-3 Binding Protein, Mac-2 Binding Protein). (2013) EP2566878 (A1).
2.
Patra, A. K. et al. An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development. Nat Immunol 14, 127–135 (2013). (Article).
3.
Vaeth, M. et al. Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 109, 16258–16263 (2012). (Article).
4.
Gerlach, K. et al. Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis. Cancer Res. 72, 4340–4350 (2012). (Article).
5.
Bhattacharyya, S. et al. NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signaling network. J. Exp. Med. 208, 823–839 (2011). (Article).
6.
Radbruch, A. et al. Method for in-Vitro Detecting Pathogenic T Helper Cells and Pharmaceutical Compositions for Treating Autoimmune Diseases. (2010). EP2223107 (A1).
7.
Flach, H. et al. Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells. Immunity 33, 723–735 (2010). (Article).
8.
Zanoni, I. et al. CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation. Nature 460, 264–268 (2009). (Article).
9.
Ullerås, E. et al. NFAT but not NF-kappaB is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells. Blood 111, 3081–3089 (2008). (Article).
10.
Niesner, U. et al. Autoregulation of Th1-mediated inflammation by twist1. J Exp Med 205, 1889–1901 (2008). (Article).
11.
Klein-Hessling, S. et al. Cyclic AMP-induced Chromatin Changes Support the NFATc-mediated Recruitment of GATA-3 to the Interleukin 5 Promoter. J. Biol. Chem. 283, 31030–31037 (2008). (Article).
12.
Akimzhanov, A. et al. Epigenetic Changes and Suppression of the Nuclear Factor of Activated T Cell 1 (NFATC1) Promoter in Human Lymphomas with Defects in Immunoreceptor Signaling. Am J Pathol 172, 215–224 (2008). (Article).
13.
Klein, M. et al. Specific and Redundant Roles for NFAT Transcription Factors in the Expression of Mast Cell-Derived Cytokines. J Immunol 177, 6667–6674 (2006). (Article).
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