Article #:
0102-05
Antigen/Product:
NFATc1, nuclear factor of activated T-cells
Synonym(s):
NFATc1, NF-ATc, NF-ATc1, NFAT transcription complex cytosolic component, NFAT2, NFATc, Nuclear factor of activated T-cells c1, Nuclear factor of activated T-cells cytoplasmic 1
Uni-/SwissProt #:
O95644, Q12865, Q15793
Clone / Name:
IG-205
Host Species:
rabbit
Mono-/polyclonal:
polyclonal (pAB) | anti-(partial sequence)
Purity:
affinity purified on the antigen
Quantity (mass):
50 µg
Quantity (vol.):
100 µl
Price (net):
215.00 €
Cross-reactivity:
human
Applications:
WB - Western blot / immunoblot, IF - immunofluorescence, IHC - immuno-histochemistry, IP - immunoprecipitation, ChIP - chromatin immunoprecipitation
Sugg. dilutions:
WB: (1:500-1:1,000); IP: (1:200), band shift assays
Remarks:
Competes with probe for NFAT binding in band shift assays.
Form:
sterile filtered liquid, with sodium azide, stabilized with carrier
Immunization:
recombinant protein (partial sequence)
Epitope:
N-terminal half of the protein
Storage:
-20°C
Shipping:
cold pack
Availability:
in stock
Data sheet:
Publications referring to this product:
1.
Patra, A. K. et al. An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development. Nat Immunol 14, 127–135 (2013). (Article).
2.
Hock, M. et al. NFATc1 induction in peripheral T and B lymphocytes. J. Immunol. 190, 2345–2353 (2013). (Article).
3.
Bhattacharyya, S. et al. NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signaling network. J. Exp. Med. 208, 823–839 (2011). (Article).
4.
Nayak, A. et al. Sumoylation of the Transcription Factor NFATc1 Leads to Its Subnuclear Relocalization and Interleukin-2 Repression by Histone Deacetylase. J. Biol. Chem. 284, 10935–10946 (2009). (Article).
5.
Silbermann, K., Schneider, G. & Grassmann, R. Stimulation of interleukin-13 expression by human T-cell leukemia virus type 1 oncoprotein Tax via a dually active promoter element responsive to NF-κB and NFAT. J Gen Virol 89, 2788–2798 (2008). (Article).
6.
Klein-Hessling, S. et al. Cyclic AMP-induced Chromatin Changes Support the NFATc-mediated Recruitment of GATA-3 to the Interleukin 5 Promoter. J. Biol. Chem. 283, 31030–31037 (2008). (Article).
7.
Akimzhanov, A. et al. Epigenetic Changes and Suppression of the Nuclear Factor of Activated T Cell 1 (NFATC1) Promoter in Human Lymphomas with Defects in Immunoreceptor Signaling. Am J Pathol 172, 215–224 (2008). (Article).
8.
Klein, M. et al. Specific and Redundant Roles for NFAT Transcription Factors in the Expression of Mast Cell-Derived Cytokines. J Immunol 177, 6667–6674 (2006). (Article).
9.
Glazova, M. et al. Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells. Brain Res. Mol. Brain Res. 138, 116–123 (2005). (Article).
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