Article #:
0122-03
Antigen/Product:
Selenoprotein P
Synonym(s):
SePP, Selenoprotein P, SeP, SePP, Sepp1
Uni-/SwissProt #:
Clone / Name:
IG-617
Host Species:
rabbit
Mono-/polyclonal:
polyclonal (pAB) | epitope selective
Purity:
affinity purified on the antigen
Quantity (mass):
30 µg
Quantity (vol.):
200 µl
Price (net):
325.00 €
Cross-reactivity:
mouse
Applications:
WB - Western blot / immunoblot, IF - immunofluorescence, IHC - immuno-histochemistry
Sugg. dilutions:
1:200-1:2000
Fixatives tested:
paraffin
Remarks:
Does not cross-react with human SePP, other species not tested.
Specificity:
In mouse serum the antibody detects three bands of approximately 50
kDa, 40 kDa, and 34 kDa, which correspond in size to the glycosylated
and non-glycosylated protein, and a
putative degradation product, respectively. All of these bands are
missing in serum
of SePP-/- knock-out mice, showing the specificity for SePP.
Form:
sterile filtered liquid, with sodium azide, carrier-free
Immunization:
synthetic peptide
Storage:
-20°C
Shipping:
RT - ambient temperature
Availability:
in stock
Data sheet:
Figure(s):
Publications referring to this product:
- Renko K., Werner M., Renner-Müller I., Cooper T.G., Yeung C.H., Hollenbach, B. Scharpf M., Köhrle J., Schomburg L. & Schweizer U. Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice. Biochem. J. 409, 741-749 (2008).
- Chiu-Ugalde J. , Theilig F., Behrends Th., Drebes J., Sieland C., Subbarayal P., Köhrle J., Hammes A., Schomburg L. & Schweizer U. Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain. Biochem J. 431(1):103-11 (2010).
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