Article #:
0042-05
Antigen/Product:
alpha-Actinin 4
Synonym(s):
α-Actinin 4
Clone / Name:
IG-701
Host Species:
rabbit
Mono-/polyclonal:
polyclonal (pAB) | epitope selective
Purity:
affinity purified on the antigen
Quantity (mass):
50 µg
Quantity (vol.):
200 µl
Price (net):
295.00 €
Cross-reactivity:
human, mouse, rat, pig
Applications:
WB - Western blot / immunoblot, IF - immunofluorescence, IHC - immuno-histochemistry, IP - immunoprecipitation
Sugg. dilutions:
WB 1:2,500 | IF 1:250- 1:1,600 | IP 1:10
Fixatives tested:
formaldehyde
Form:
sterile filtered liquid, with sodium azide, stabilized with carrier
Immunization:
synthetic peptide
Epitope:
close to N-terminal peptide specific for isoform 4
Storage:
-20°C
Shipping:
RT - ambient temperature
Availability:
in stock
Data sheet:
Figure(s):
Publications referring to this product:
1.
Bhatnagar, A. et al. Interaction of G-protein βγ complex with chromatin modulates GPCR-dependent gene regulation. PLoS ONE 8, e52689 (2013). (Article).
2.
Jayadev, R., Kuk, C. Y., Low, S. H. & Murata-Hori, M. Calcium sensitivity of α-actinin is required for equatorial actin assembly during cytokinesis. Cell Cycle 11, 1929–1937 (2012). (Article).
3.
Meyer-Schwesinger, C. et al. Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy. Am. J. Pathol. 178, 2044–2057 (2011). (Article).
4.
Meyer-Schwesinger, C. et al. Nephrotic Syndrome and Subepithelial Deposits in a Mouse Model of Immune-Mediated Anti-Podocyte Glomerulonephritis. J Immunol 187, 3218–3229 (2011). (Article).
5.
Hartleben, B. et al. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. Journal of Clinical Investigation 120, 1084–1096 (2010). (Article).
6.
Yang, C. & Glass, W. F. Expression of α-Actinin-1 in Human Glomerular Mesangial Cells In Vivo and In Vitro. Experimental Biology and Medicine 233, 689–693 (2008). (Article).
7.
Kimura, M. et al. Expression of alpha-actinin-4 in human diabetic nephropathy. Intern. Med. 47, 1099–1106 (2008). (Article).
8.
Mukhina, S., Wang, Y.-L. & Murata-Hori, M. Alpha-actinin is required for tightly regulated remodeling of the actin cortical network during cytokinesis. Dev. Cell 13, 554–565 (2007). (Article).
9.
Bolshakova, A. et al. Extra-cellular matrix proteins induce re-distribution of alpha-actinin-1 and alpha-actinin-4 in A431 cells. Cell Biol. Int. 31, 360–365 (2007). (Article).
10.
Galler, A. B. et al. VASP-dependent regulation of actin cytoskeleton rigidity, cell adhesion, and detachment. Histochem. Cell Biol. 125, 457–474 (2006). (Article).
11.
Bariety, J., Mandet, C., Hill, G. S. & Bruneval, P. Parietal Podocytes in Normal Human Glomeruli. JASN 17, 2770–2780 (2006). (Article).
12.
Iida, Y. & Chiba, H. The Relationship between Subcellular Localization of Actinin-4 and Cell Motility in Oral Squamous Cell Carcinoma. Oral Science International 1, 30–37 (2004). (Article).
13.
Goode, N. P., Shires, M., Khan, T. N. & Mooney, A. F. Expression of α-actinin-4 in acquired human nephrotic syndrome: a quantitative immunoelectron microscopy study. Nephrol. Dial. Transplant. 19, 844–851 (2004). (Article).
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