Article #:
0142-10
Antigen/Product:
Lat-2, Slc7a8
Synonym(s):
Lat 2 / Lat2
Uni-/SwissProt #:
Clone / Name:
Lat 2
Host Species:
rabbit
Mono-/polyclonal:
polyclonal (pAB) | epitope selective
Purity:
affinity purified on the antigen
Quantity (mass):
100 µg
Quantity (vol.):
200 µl
Price (net):
245.00 €
Cross-reactivity:
mouse, rat
Applications:
WB - Western blot / immunoblot, IF - immunofluorescence, IHC - immuno-histochemistry
Sugg. dilutions:
WB: 1:1,000 (0.5 µg/ml); IHC: 1:250 (2 µg/ml)
Fixatives tested:
formaldehyde
Remarks:
The antibody detects a ~ 50 kDa Lat 2 band in wild type mouse brain, kidney, jejunum, ileum, and other tissues, which is absent in knock-out animals. In some tissues the antibody labels an additional unknown 38 kDa band [Braun et al. 2011]
Form:
sterile filtered liquid, with sodium azide, stabilized with carrier
Immunization:
synthetic peptide
Storage:
-20°C
Shipping:
RT - ambient temperature
Availability:
in stock
Data sheet:
Figure(s):
Publications referring to this product:
1.
Braun, D. et al. Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8. Biochem. J. 439, 249–255 (2011). (Article).
2.
Wirth, E. K. et al. Neuronal 3’,3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. J. Neurosci. 29, 9439–9449 (2009). (Article).
3.
Hinz, K. M. et al. Structural insights into thyroid hormone transport mechanisms of the L-type amino acid transporter 2. Mol. Endocrinol. 29, 933-42. (2015). (Article)
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